National Awards “Science and Research”
NEW! RJID has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.
Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.
The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.
DESCRIPTION AND NOMENCLATURE OF NEISSERIA MENINGITIDIS CAPSULE LOCUS
Odile B. Harrison, Heike Claus, Ying Jiang, Julia S. Bennett, Holly B. Bratcher, Keith A. Jolley, Craig Corton, Rory Care, Jan T. Poolman, Wendell D. Zollinger, Carl E. Frasch, David S. Stephens, Ian Feavers, Matthias Frosch, Julian Parkhill, Ulrich Vogel, Michael A. Quail, Stephen D. Bentley and Martin C.J. Maiden
Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.