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A CASE OF GIANT RAPID EVOLVING BUSCHKE-LOWENSTEIN TUMOR IN AN IMMUNOCOMPETENT PATIENT
Buschke-Löwenstein tumor (BLT) is a rare premalignant disorder, with a considerable potential of malignant transformation into squamous cell carcinoma; HPV infection (especially HPV 6 and HPV 11) have an important role in the ethiopathogeny of the disease, along with immunosuppression- usually caused by HIV virus, a frequently encountered association. We report on the case of a 47 year old male patient who addresses our clinic for the occurrence of a giant tumoral lesion located in the intergluteal cleft, which had rapidly evolved despite the repeatedly negative HIV testing. The histopathologic examination confirms the clinical diagnosis of BLT; wide surgical excision of the tumor with safety margins was not followed by recurrence, during a follow-up period that exceeded 12 months. The case is distinguished through the large dimensions of the tumor, the extremely rare anatomical situation and the rapid evolution, despite the absence of HIV immunosuppression.
Key words: Giant condyloma acuminata, Buschke-Löwenstein tumor, human papillomavirus, squamous cell carcinoma