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Manole Cojocaru

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Articole semnate de acelasi autor in Revista Romana de Boli Infectioase:

MEDICAMENTELE ANTIFUNGICE SI DEZVOLTAREA MECANISMELOR DE REZISTENTA LA UNELE SPECII DE DROJDII

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Romanian Journal of Infectious Diseases | Vol. XVI, No. 4, Year 2013
ISSN 1454-3389  |  e-ISSN 2069-6051
ISSN-L 1454-3389
DOI: 10.37897/RJID

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MEDICAMENTELE ANTIFUNGICE SI DEZVOLTAREA MECANISMELOR DE REZISTENTA LA UNELE SPECII DE DROJDII

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REZUMAT

Candidozele sunt cele mai întâlnite infecţii cauzate de fungi, reprezentând aproximativ jumatate din totalul infecţiilor micotice. Patologia fungică a înregistrat în ultimii ani o frecvenţă foarte crescută. Factorii care contribuie la această oportunitate a infecţiilor sunt: slăbirea sistemului imunitar, greutate scăzută la naştere, creşterea numărului de pacienţi infectaţi cu HIV, chimioterapia pe termen lung, creşterea utilizării dispozitivelor protetice şi a cateterelor vasculare, tratamentele cu corticoizi şi antibiotice cu spectru larg. Al doilea motiv pentru creşterea infecţiilor cauzate de Candida albicans este existenţa multor compuşi cu activitate antifungică. Aceştia se administrează cu precauţie din cauza toxicităţii lor şi a efectelor secundare. Datorită necesităţii de a combate infecţiile cauzate de fungi, studiul substanţelor antifungice este în plină dezvoltare. Cele mai cunoscute şi utilizate substanţe cu activitate antifungică au ca ţintă ergosterolul (principalul sterol al membranelor fungice), biosinteza ergosterolului, biosinteza β-1,3-D-glucanului şi biosinteza ADN.

Cuvinte cheie: Candida, antifungice, rezistenţă

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RESISTANCE ON ANTIBIOTIC DRUGS AND INCIDENCE OF SOME BACTERIA SPECIES IN URINARY TRACT INFECTIONS

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Romanian Journal of Infectious Diseases | Vol. XVII, No. 1, Year 2014
ISSN 1454-3389  |  e-ISSN 2069-6051
ISSN-L 1454-3389
DOI: 10.37897/RJID

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RESISTANCE ON ANTIBIOTIC DRUGS AND INCIDENCE OF SOME BACTERIA SPECIES IN URINARY TRACT INFECTIONS

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ABSTRACT

Objectives. The aim of our study was to determine the urinary infection incidence caused by different microbial species and the sensitivity to the different antibiotics classes.

Materials and methods. We observed a lot of 638 patients which were hospitalized in Gerota Hospital from Bucharest during six weeks for different pathologies (gastroenteritis, cardiovascular disease, pneumonitis, and urinary tract infections).

Results. From the total number of patients, 100 were done positive for urinary tract infections. The predominant species was E. coli (65%) followed by Enterococcus species (15%), Proteus species (10%), Enterobacter species (6%), Pseudomonas aeruginosa (3%) and Staphylococcus aureus (1%). The incidence E. coli species was 57% for women and 23% for men. Six strains were susceptibility only to imipenen and resistant to all antibiotics used (four E. coli strains and two Enterobacter strains). Five of these were from men and one from a woman. Incidence of antibiotic drugs resistance was 45% for gentamicin, 43% for cefaclor, 43% for tetracycline, 21.5% for ciprofloxacin, and 26% for amoxicillin and clavulanic acid for E. coli strains.

Conclusion. Most of identified strains belong to Escherichia coli species and have a great resistance to antibiotic drugs.

Keywords: E. coli, antibiotics, resistance

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INFLUENCE OF ASSOCIATING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS WITH ANTIFUNGAL COMPOUNDS ON VIABILITY OF SOME CANDIDA STRAINS

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Romanian Journal of Infectious Diseases | Vol. XVII, No. 2, Year 2014
ISSN 1454-3389  |  e-ISSN 2069-6051
ISSN-L 1454-3389
DOI: 10.37897/RJID

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ICMJE- Recommendations

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Promoting Global Health

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INFLUENCE OF ASSOCIATING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS WITH ANTIFUNGAL COMPOUNDS ON VIABILITY OF SOME CANDIDA STRAINS

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ABSTRACT

Objective. The main goal of our study was to determine the effect that association of nonsteroidal anti-in- flammatory drugs (NSAIDs) with antifungal drugs on viability of Candida (C.) albicans and C. krusei species. Materials and methods. Six yeast strains were isolated from pharyngeal and vaginal secretions (C. albicans and C. krusei). Tests (diffusion and serial microdilutions methods) were carried out in the presence of some NSAIDs by using different concentrations (0.25mg/ml and 1mg/ml). Antifungal drugs were used in lower concentrations than the MIC (1μg/ml). Results. Cell viability of C. krusei strain was of 82% for NSAIDs used and association of these with ketoconazole led to decrease of cell viability of C. krusei strain to 60% as compared to the cells treated with antifungal drugs. In the presence of NSAIDs, cell viability of C. albicans strains, decreased between 6 to 18% for diclofenac and ibuprofen. In the case of simultaneous use of the two classes of drugs, there was observed an increase of antimicrobial activity, especially for diclofenac association, cell viability was reduced up to 60% and respectively 70% as compared to the cells treated only with ketoconazole and fluconazole. Conclusion. We observed a synergistic action of certain NSAIDs with two antifungal drugs used on some Candida species.

Keywords: Candida, Cell viability, NSAID

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EVALUAREA EFECTULUI ANTIMICROBIAN AL UNOR SPECII DE BACTERII LACTICE

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Romanian Journal of Infectious Diseases | Vol. XVIII, No. 1, 2015
ISSN 1454-3389  |  e-ISSN 2069-6051
ISSN-L 1454-3389
DOI: 10.37897/RJID

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ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

EVALUAREA EFECTULUI ANTIMICROBIAN AL UNOR SPECII DE BACTERII LACTICE

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REZUMAT

La nivelul tubului gastrointestinal există un echilibru între flora microbiotă şi tractul digestiv, care are ca efect diferenţierea speciilor comensale de speciile bacteriene patogene. Datorită dezvoltării de noi terapii şi utilizării unor compuşi antimicrobieni cu spectru larg de acţiune, în ultima perioadă s-a observat o creştere a numărului de infecţii oportuniste cauzate de tulpini bacteriene şi fungice potenţial patogene. Bacteriile lactice produc compuşi cu activitate antimicrobiană, cum ar fi peroxidul de hidrogen, diacetil, acetaldehidă, izomeri D- ai aminoacizilor, reuterin şi bacteriocine. Utilizarea probioticelor poate reprezenta o alternativă suplimentară în vederea creşterii şi menţinerii stării de sănătate a organismului uman.

Cuvinte cheie: bacterii lactice, antimicrobian, infecţii

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