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Ionela Sarbu

Latest posts by Ionela Sarbu (see all)

  • ANALIZE PRIVIND ACTIVITATEA ANTIMICROBIANA A UNOR TULPINI DE BACTERII LACTICE - 11/11/2015
  • INFLUENCE OF ASSOCIATING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS WITH ANTIFUNGAL COMPOUNDS ON VIABILITY OF SOME CANDIDA STRAINS - 07/08/2015

Articole semnate de acelasi autor in Revista Romana de Boli Infectioase:

ANALIZE PRIVIND ACTIVITATEA ANTIMICROBIANA A UNOR TULPINI DE BACTERII LACTICE

SELECT ISSUE

Romanian Journal of Infectious Diseases | Vol. XVIII, No. 2-3, 2015
ISSN 1454-3389  |  e-ISSN 2069-6051
ISSN-L 1454-3389
DOI: 10.37897/RJID

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National Awards “Science and Research”

NEW! RJID has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ANALIZE PRIVIND ACTIVITATEA ANTIMICROBIANA A UNOR TULPINI DE BACTERII LACTICE

Ionela Sarbu, Tatiana Vassu, Ileana Stoica, Carmen Chifiriuc, Marcela Bucur, Elena Rusu, Robertina Ionescu and Diana Pelinescu

REZUMAT

Obiectiv. Scopul principal al acestui studiu a constat în selecţia unui grup de bacterii lactice cu activitate antimicrobiană ridicată, identificarea compuşilor cu acţiune antimicrobiană şi caracterizarea acestora.

Material şi metode. S-a determinat activitatea antimicrobiană a 153 de tulpini de bacterii lactice prin metoda difuzimetrică faţă de 6 tulpini microbiene patogene izolate de la pacienţi cu infecţii urinare şi vaginale.

Rezultate. În urma obţinerii rezultatelor, s-a constatat că majoritatea tulpinilor de bacterii lactice au prezentat o activitate antimicrobiană ridicată faţă de bacteriile patogene, cât şi faţă de tulpinile de drojdii. Activitatea antimicrobiană a bacteriilor lactice a fost corelată în special cu producerea de acizi organici, iar în cazul a două tulpini aceasta a fost corelată cu biosinteza de bacteriocine. Bacteriocina produsă de tulpina Lactococcus (Lc.) lactis F2a a prezentat un spectru larg de acţiune şi o activitate ridicată (51.200 UA/ml), comparativ cu bacteriocina izolată de la tulpina Lactobacillus (Lb.) paracasei ssp. paracasei JR (400 UA/ml). În ceea ce priveşte stabilitatea bacteriocine produse de tulpina Lc. lactis F2a, aceasta este mai stabilă la pH acid decât la pH bazic, expunerea în timp la o temperatură medie de 600C determină o scădere drastică a activităţii bacteriocinei.

Concluzii. Bacteriile lactice utilizate au prezentat o activitate antimicrobiană ridicată atât faţă de tulpini patogene procariote, cât şi eucariote. Dintre cele două bacteriocine analizate, bacteriocina izolată de la tulpina Lc. lactis F2a a prezentat o activitate ridicată şi un spectru larg de acţiune.

Cuvinte cheie: bacterii lactice, probiotice, bacteriocine

Full text | PDF

INFLUENCE OF ASSOCIATING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS WITH ANTIFUNGAL COMPOUNDS ON VIABILITY OF SOME CANDIDA STRAINS

SELECT ISSUE

Romanian Journal of Infectious Diseases | Vol. XVII, No. 2, Year 2014
ISSN 1454-3389  |  e-ISSN 2069-6051
ISSN-L 1454-3389
DOI: 10.37897/RJID

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJID has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

INFLUENCE OF ASSOCIATING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS WITH ANTIFUNGAL COMPOUNDS ON VIABILITY OF SOME CANDIDA STRAINS

Elena Rusu, Ionela Sarbu, Diana Pelinescu, Ioana Nedelcu, Tatiana Vassu, Cristina Cristescu, Simona Musat and Manole Cojocaru

ABSTRACT

Objective. The main goal of our study was to determine the effect that association of nonsteroidal anti-in- flammatory drugs (NSAIDs) with antifungal drugs on viability of Candida (C.) albicans and C. krusei species. Materials and methods. Six yeast strains were isolated from pharyngeal and vaginal secretions (C. albicans and C. krusei). Tests (diffusion and serial microdilutions methods) were carried out in the presence of some NSAIDs by using different concentrations (0.25mg/ml and 1mg/ml). Antifungal drugs were used in lower concentrations than the MIC (1μg/ml). Results. Cell viability of C. krusei strain was of 82% for NSAIDs used and association of these with ketoconazole led to decrease of cell viability of C. krusei strain to 60% as compared to the cells treated with antifungal drugs. In the presence of NSAIDs, cell viability of C. albicans strains, decreased between 6 to 18% for diclofenac and ibuprofen. In the case of simultaneous use of the two classes of drugs, there was observed an increase of antimicrobial activity, especially for diclofenac association, cell viability was reduced up to 60% and respectively 70% as compared to the cells treated only with ketoconazole and fluconazole. Conclusion. We observed a synergistic action of certain NSAIDs with two antifungal drugs used on some Candida species.

Keywords: Candida, Cell viability, NSAID

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