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Revista Romana de Boli Infectioase | Vol. XIX, No. 3, 2016
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398

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THE MANAGEMENT OF B HEPATITIS VIRUS INFECTION IN RELATION WITH HUMAN REPRODUCTION

ABSTRACT

The HBV infection is a major public health problem. It is estimated that worldwide around 2 billion people have markers that show they passed through this infection.
In the majority of the cases of HBV infection occurring in adult patients, the natural evolution is towards HBs Ag clearance (which is though not equivalent in all the cases with complete healing as the virus may persist in the hepatocytes in the form of cccDNA). The situation is completely different when the infection is contracted perinatal (intra- or post- partum or more rarely intrauterine) as in these patients, most frequently the infection evolves to chronic forms, either active or inactive or in the form of immune-tolerance. The vertical transmission of HBV infection represents the main problem regarding the management of this infection in pregnancy.
In the following review of the literature I synthetized the data regarding the impact of HBV infection on pregnancy as well as the impact of pregnancy on HBV infection. I also searched data regarding the possibility of father-to-offspring transmission and I tried to clarify the mechanisms that make the transmission possible. Finally, I synthetized the existing recommendations in algorithms that are dedicated to ease the activity of the infectious diseases specialist that has to deal with such cases.

Keywords: B hepatitis, pregnancy, vertical transmission, HBV, prevention

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